Table 2

Inflammation and osteoblast-associated genes over-expressed in proteoglycan-induced spondylitis (PGISp) spines

Gene

Fold change PGISp/Control

P-value

Gene symbol


Matrix metallopeptidase 3

5.29

3.50E-05

Mmp3

Matrix metallopeptidase 13

2.26

0.0086

Mmp13

Tissue inhibitor of metalloproteinase 1

3.48

0.0003

Timp1

Interleukin 1, beta

1.57

0.0087

Il1b

Interleukin 1 receptor, type II

1.28

0.0000

Il1r2

interleukin 28 receptor alpha

1.18

0.0068

Il28ra

Signal transducer and activator of transcription 1

1.18

0.0150

Stat1

Signal transducer and activator of transcription 3

1.21

0.0039

Stat3

Bone sialoprotein

2.62

0.0001

Ibsp

Collagen Type I

2.51

0.0005

Col1a1

Collagen Type III

2.42

0.0004

Col3a1

Osteocalcin

1.50

0.0297

Bglap1


Haynes et al. Arthritis Research & Therapy 2012 14:R253   doi:10.1186/ar4096

Open Data