Table 3

Haplotype frequencies and meta-analysis of PADI4 polymorphisms in relation to RA in the MyEIRA study

Block

Ethnicity

Haplotype frequency

Ratio counts (case, control)

Frequencies (case, control)

χ2

P value

OR (95% CI)

Meta-analysis

Phet

I2 (%)


ACGG

Malay

0.501

510.8:537.2, 984.2:951.8

0.487, 0.508

1.195

0.2744

0.92 (0.79 to 1.07)

0.91 (0.82 to 1.02), Z = 1.62 (P = 0.10)

0.64

0

Chinese

0.567

288.8:217.2, 224.7:175.3

0.571, 0.562

0.076

0.7835

1.04 (0.80 to 1.35)

Indian

0.413

292.7:453.3, 246.1:313.9

0.392, 0.439

2.919

0.0875

0.83 (0.66 to 1.03)

Others

0.46

78.8:97.2, 88.6:99.4

0.447, 0.471

0.204

0.6519

0.91 (0.60 to 1.37)


ATAA

Malay

0.055

42.5:1,005.5, 120.7:1,815.3

0.041, 0.062

6.226

0.0126

0.64 (0.45 to 0.92)

0.71 (0.54-0.94), Z = 2.42 (P = 0.02)

0.78

0

Chinese

0.064

29.0:477.0, 29.0:371.0

0.057, 0.073

0.86

0.3537

0.78 (0.46 to 1.32)

Indian

0.015

9.7:736.3, 9.3:550.7

0.013, 0.017

0.293

0.5886

0.83 (0.34 to 2.06)

Others

0.039

7.3:168.7, 7.0:181.0

0.042, 0.037

0.046

0.8296

1.07 (0.37 to 3.12)


ATAG

Malay

0.287

333.6:714.4, 522.9:1,413.1

0.318, 0.270

7.736

0.0054

1.26 (1.07 to 1.49)

1.21 (1.08-1.36), Z = 3.20 (P = 0.001)

0.78

0

Chinese

0.274

140.8:365.2, 107.1:292.9

0.278, 0.268

0.128

0.7202

1.06 (0.79 to 1.42)

Indian

0.398

312.4:433.6, 207.6:352.4

0.419, 0.371

3.09

0.0788

1.22 (0.97 to 1.52)

Others

0.34

62.5:113.5, 61.4:126.6

0.355, 0.326

0.336

0.562

1.16 (0.75 to 1.79)


ATGG

Malay

0.096

108.7:939.3, 178.8:1,757.2

0.104, 0.092

1.001

0.317

1.14 (0.89 to 1.46)

1.02 (0.77-1.36), Z = 0.14 (P = 0.89)

0.24

29

Chinese

0.046

23.2:482.8, 18.3:381.7

0.046, 0.046

0.0

0.9908

1.01 (0.54 to 1.90)

Indian

0.049

39.1:706.9, 25.3:534.7

0.052, 0.045

0.351

0.5538

1.18 (0.71 to 1.97)

Others

0.091

11.0:165.0, 22.0:166.0

0.063, 0.117

3.268

0.0706

0.50 (0.24 to 1.07)


GTAG

Malay

0.041

38.6:1,009.4, 83.8:1,852.2

0.037, 0.043

0.714

0.398

0.85 (0.58 to 1.26)

0.94 (0.72-1.21), Z = 0.49 (P = 0.63)

0.59

0

Chinese

0.042

20.1:485.9, 17.9:382.1

0.040, 0.045

0.138

0.7099

0.87 (0.46 to 1.67)

Indian

0.065

47.9:698.1, 37.1:522.9

0.064, 0.066

0.023

0.8798

0.97 (0.62 to 1.51)

Others

0.046

10.4:165.6, 6.4:181.6

0.059, 0.034

1.326

0.2496

1.83 (0.65 to 5.14)


CI, confidence interval; I2, degree of heterogeneity (%); MyEIRA, Malaysian Epidemiological Investigation of Rheumatoid Arthritis; OR, odds ratio; PADI, peptidylarginine deiminase; Phet, P value for heterogeneity; RA, rheumatoid arthritis.

Too et al. Arthritis Research & Therapy 2012 14:R250   doi:10.1186/ar4093

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