Table 3 |
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|
Haplotype frequencies and meta-analysis of PADI4 polymorphisms in relation to RA in the MyEIRA study |
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|
Block |
Ethnicity |
Haplotype frequency |
Ratio counts (case, control) |
Frequencies (case, control) |
χ2 |
P value |
OR (95% CI) |
Meta-analysis |
Phet |
I2 (%) |
|
|
||||||||||
|
ACGG |
Malay |
0.501 |
510.8:537.2, 984.2:951.8 |
0.487, 0.508 |
1.195 |
0.2744 |
0.92 (0.79 to 1.07) |
0.91 (0.82 to 1.02), Z = 1.62 (P = 0.10) |
0.64 |
0 |
|
Chinese |
0.567 |
288.8:217.2, 224.7:175.3 |
0.571, 0.562 |
0.076 |
0.7835 |
1.04 (0.80 to 1.35) |
||||
|
Indian |
0.413 |
292.7:453.3, 246.1:313.9 |
0.392, 0.439 |
2.919 |
0.0875 |
0.83 (0.66 to 1.03) |
||||
|
Others |
0.46 |
78.8:97.2, 88.6:99.4 |
0.447, 0.471 |
0.204 |
0.6519 |
0.91 (0.60 to 1.37) |
||||
|
|
||||||||||
|
ATAA |
Malay |
0.055 |
42.5:1,005.5, 120.7:1,815.3 |
0.041, 0.062 |
6.226 |
0.0126 |
0.64 (0.45 to 0.92) |
0.71 (0.54-0.94), Z = 2.42 (P = 0.02) |
0.78 |
0 |
|
Chinese |
0.064 |
29.0:477.0, 29.0:371.0 |
0.057, 0.073 |
0.86 |
0.3537 |
0.78 (0.46 to 1.32) |
||||
|
Indian |
0.015 |
9.7:736.3, 9.3:550.7 |
0.013, 0.017 |
0.293 |
0.5886 |
0.83 (0.34 to 2.06) |
||||
|
Others |
0.039 |
7.3:168.7, 7.0:181.0 |
0.042, 0.037 |
0.046 |
0.8296 |
1.07 (0.37 to 3.12) |
||||
|
|
||||||||||
|
ATAG |
Malay |
0.287 |
333.6:714.4, 522.9:1,413.1 |
0.318, 0.270 |
7.736 |
0.0054 |
1.26 (1.07 to 1.49) |
1.21 (1.08-1.36), Z = 3.20 (P = 0.001) |
0.78 |
0 |
|
Chinese |
0.274 |
140.8:365.2, 107.1:292.9 |
0.278, 0.268 |
0.128 |
0.7202 |
1.06 (0.79 to 1.42) |
||||
|
Indian |
0.398 |
312.4:433.6, 207.6:352.4 |
0.419, 0.371 |
3.09 |
0.0788 |
1.22 (0.97 to 1.52) |
||||
|
Others |
0.34 |
62.5:113.5, 61.4:126.6 |
0.355, 0.326 |
0.336 |
0.562 |
1.16 (0.75 to 1.79) |
||||
|
|
||||||||||
|
ATGG |
Malay |
0.096 |
108.7:939.3, 178.8:1,757.2 |
0.104, 0.092 |
1.001 |
0.317 |
1.14 (0.89 to 1.46) |
1.02 (0.77-1.36), Z = 0.14 (P = 0.89) |
0.24 |
29 |
|
Chinese |
0.046 |
23.2:482.8, 18.3:381.7 |
0.046, 0.046 |
0.0 |
0.9908 |
1.01 (0.54 to 1.90) |
||||
|
Indian |
0.049 |
39.1:706.9, 25.3:534.7 |
0.052, 0.045 |
0.351 |
0.5538 |
1.18 (0.71 to 1.97) |
||||
|
Others |
0.091 |
11.0:165.0, 22.0:166.0 |
0.063, 0.117 |
3.268 |
0.0706 |
0.50 (0.24 to 1.07) |
||||
|
|
||||||||||
|
GTAG |
Malay |
0.041 |
38.6:1,009.4, 83.8:1,852.2 |
0.037, 0.043 |
0.714 |
0.398 |
0.85 (0.58 to 1.26) |
0.94 (0.72-1.21), Z = 0.49 (P = 0.63) |
0.59 |
0 |
|
Chinese |
0.042 |
20.1:485.9, 17.9:382.1 |
0.040, 0.045 |
0.138 |
0.7099 |
0.87 (0.46 to 1.67) |
||||
|
Indian |
0.065 |
47.9:698.1, 37.1:522.9 |
0.064, 0.066 |
0.023 |
0.8798 |
0.97 (0.62 to 1.51) |
||||
|
Others |
0.046 |
10.4:165.6, 6.4:181.6 |
0.059, 0.034 |
1.326 |
0.2496 |
1.83 (0.65 to 5.14) |
||||
|
|
||||||||||
|
CI, confidence interval; I2, degree of heterogeneity (%); MyEIRA, Malaysian Epidemiological Investigation of Rheumatoid Arthritis; OR, odds ratio; PADI, peptidylarginine deiminase; Phet, P value for heterogeneity; RA, rheumatoid arthritis. |
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|
Too et al. Arthritis Research & Therapy 2012 14:R250 doi:10.1186/ar4093 |
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