Table 2

Significant SNP variants associated with ACPA-positive and ACPA-negative RA in the MyEIRA study population

Ethic group

SNP variant

Risk allele

Ratio counts (case, control)

Frequencies (case, control)

χ2

P value


ACPA-positive RA

Malay

rs12042956

G

50:562, 103:1819

0.082, 0.054

6.465

0.011

Malay

rs7538876

G

496:122, 1480:478

0.803, 0.756

5.738

0.0166

Malay

rs2526839

C

240:378, 667:1291

0.388, 0.341

4.684

0.0304

Chinese

rs3003444

A

247:83, 262:142

0.748, 0.649

8.539

0.0035

Chinese

rs2977299

G

223:107, 235:169

0.676, 0.582

6.851

0.0089

Chinese

rs3766298

A

223:107, 234:168

0.676, 0.582

6.779

0.0092

Indian

rs113475583

G

481:21, 532:44

0.958, 0.924

5.653

0.0174

Indian

rs72633848

A

483:21, 536:44

0.958, 0.924

5.594

0.018

Indian

rs35903413

G

498:6, 564:16

0.988, 0.972

3.335

0.0678

ACPA-negative RA

Malay

rs16825533

G

67:337, 227:1731

0.166, 0.116

7.654

0.0057

Malay

rs57744451

G

67:339, 234:1724

0.165, 0.120

6.269

0.0123

Malay

rs2240337

G

388:14, 1826:128

0.965, 0.934

5.541

0.0186

Chinese

rs3003444

A

125:43, 262:142

0.744, 0.649

4.949

0.0261

Chinese

rs12037558

A

113:53, 237:167

0.681, 0.587

4.395

0.036

Chinese

rs2977296

G

145:23, 320:84

0.863, 0.792

3.935

0.0473

Indian

rs12042956

A

223:13, 506:64

0.945, 0.888

6.319

0.0119

Indian

rs2977305

A

242:4, 550:26

0.984, 0.955

4.088

0.0432

Indian

rs34324150

G

242:4, 552:26

0.984, 0.955

4.058

0.044


Top three significant SNP variants associated with risk of developing anti-citrullinated protein autoantibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) in three major ethnic groups from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) study population

Too et al. Arthritis Research & Therapy 2012 14:R250   doi:10.1186/ar4093

Open Data