Figure 3.

Allelic and genotypic association between PADI4 rs2240340 polymorphism and rheumatoid arthritis in Asian populations. Combined meta-analysis of (a) the allelic model and (b) the genotypic model between PADI4 rs2240340 polymorphism and risk of developing RA in Asian populations. (a) *If the first Japanese study was excluded, overall odds ratio (OR_overall) = 1.21 (1.13 to 1.29), p_het = 0.15, I² = 35%; **if the Korean study was excluded as the PADI4 rs2240340 SNP was not investigated, OR_overall = 1.21 (1.13 to 1.29), p_het = 0.23, I² = 25%; if both the first Japanese study and the Korean study were excluded, OR_overall = 1.17 (1.09 to 1.25), p_het = 0.58, I² = 0%. (b) *If the first Japanese study was excluded, OR_overall = 1.27 (1.15 to 1.40), p_het = 0.47, I² = 0%; **if the Korean study was excluded as the PADI4 rs2240340 SNP was not investigated, OR_overall = 1.28 (1.16 to 1.40), p_het = 0.58, I² = 0%; if both the first Japanese study and the Korean study were excluded, OR_overall = 1.22 (1.10 to 1.35), p_het = 0.93, I² = 0%. Minor allele (rs2240340_T) versus common allele (rs2240340_C). CI, confidence interval; MH, Mantel-Haenszel; p_het, P value for heterogeneity; I², degree of heterogeneity expressed as percentage; RA, rheumatoid arthritis.