Table 4

Association of main baseline characteristics of patients with early RA and rapid radiographic progression (RRP) of rheumatoid arthritis (univariate analysis).

With RRP

(number = 41)

Without RRP

(number = 329)

P valuea


Age, years

49.8 ± 12 (52.7)

49.3 ± 11.5 (7)

0.6

Sex

31 (75.6%)

240 (73%)

0.85

Disease duration, weeks

18.6 ± 8.4 (18.6)

14.7 ± 8.1 (13)

0.007

SJC in 28 joints

8.6 ± 6.1 (8)

7.8 ± 5.3 (7)

0.5

< 14

31 (75.6)

285 (86.6)

14 to 20

6 (14.6)

32 (9.7)

0.08

≥ 20

4 (12.2)

12 (3.6)

TJC in 28 joints

8.3 ± 6.3 (7)

8.7 ± 6.9 (7)

0.97

ESR, mm/1 hr

32.6 ± 21.3 (30)

32.7 ± 25.4 (25)

0.5

CRP, mg/L

26.2 ± 27.9 (14)

24.6 ± 38.7 (11)

0.12

< 4

4 (9.7)

89 (27.1)

4 to 35

25 (61)

168 (51.1)

0.04

≥ 35

12 (29.3.8)

72 (21.9)

Elevated ESR or CRP level

38 (90.3)

289 (87.8)

0.45

DAS28(ESR)-4v

5.3 ± 1.2 (5.4)

5.3 ± 1.2 (5.2)

0.8

RF positivity

29 (70.7)

175 (53.2)

0.04

ACPA positivity

31 (75.6)

154 (46.8)

0.0008

RF or ACPA positivity

32 (78)

190 (57.8)

0.01

HAQ score

0.95 ± 0.6 (1)

1.04 ± 0.7 (1)

0.5

Typical RA erosion

18 (44)

48 (14.6)

< 0.0001

Prednisone ≥ 7.5 mg/d

2 (4.9)

35 (10.6)

0.4

≥ 5 mg/d

7 (17.7)

91 (27.7)

0.19

Delay before 1st DMARD initiation ≥ 6 months after RA onset

22 (53.7)

147 (44.7)

0.32

Satisfaction of 2010 ACR/EULAR criteria

38 (92.7)

278 (84.5)

0.24


Data are mean ± SD (median) or number (%). RRP-positive status was defined by progression of the vSHS total score ≥ 5 points between baseline and one year (of note, among the 46 patients with RRP, 44 had progression with vSHS erosion score ≥ 5 points and 13 with vSHS narrowing score ≥ 5 points). aStudent t test or Mann-Whitney U test for continuous variables and Fischer exact test for categorical variables, with P < 0.1. ACPA, anti-citrullinated protein antibody; ACR/EULAR, American College of Rheumatology/European League Against Rheumatism; CRP, C-reactive protein; DAS28(ESR)-4v, Disease Activity Score in 28 joints-4 variables, using erythrocyte sedimentation rate; DMARD, disease-modifying anti-rheumatic drugs; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SJC, swollen joint count; TJC, tender joint count; vSHS, van der Heijde-modified Sharp score.

Fautrel et al. Arthritis Research & Therapy 2012 14:R249   doi:10.1186/ar4092

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