Table 5

Multivariable-adjusted* predictors of use of opioid pain medications after primary total knee arthroplasty

Multivariable-adjusted* analysis, 2-year follow-up

Multivariable-adjusted* analysis, 5-year follow-up


Odds ratio

(95% CI)

P-value

Odds ratio

(95% CI)

P-value


Male gender (reference female)

0.54

(0.32, 0.92)

0.02a

0.39

(0.18, 0.84)

0.02a

Age (reference ≤ 60 yrs)

> 60 to 70 yrs

0.66

(0.36, 1.20)

0.17

0.80

(0.38, 1.70)

0.57

> 70 to 80 yrs

0.27

(0.13, 0.57)

0.001a

0.34

(0.14, 0.83)

0.02a

> 80 yrs

0.48

(0.19, 1.22)

0.12

0.39

(0.10, 1.57)

0.19

Body mass index (reference < 25 kg/m2)

25.0 to 29.9

1.00

(0.46, 2.17)

1.00

0.65

(0.24, 1.74)

0.39

30.0 to 34.9

1.10

(0.50, 2.44)

0.81

0.88

(0.31, 2.47)

0.80

35.0 to 39.9

1.25

(0.49, 3.22)

0.64

0.86

(0.29, 2.58)

0.79

≥ 40.0

0.54

(0.19, 1.59)

0.27

0.40

(0.10, 1.64)

0.20

Deyo-Charlson index (5-point change)

1.28

(0.70, 2.33)

0.43

1.03

(0.48, 2.21)

0.93

Depression (reference no depression)

1.05

(0.55, 2.00)

0.88

1.91

(0.83, 4.41)

0.13

Anxiety (reference no anxiety)

3.05

(1.62, 5.72)

0.001a

3.98

(1.68, 9.43)

0.002a


*Adjusted for American Society of Anesthesiologists (ASA) score, distance from the medical center, income, operative diagnosis and implant fixation in addition to all the variables in the table; aSignificant odds ratios and P-values; CI, confidence interval. Goodness of fit statistic calculated as quasi likelihood ratio with lower value indicating a better fit: 2 years, 824.3; 5 years, 519.1.

Singh and Lewallen Arthritis Research & Therapy 2012 14:R248   doi:10.1186/ar4091

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