Table 1

Interleukin (IL)-17A-inducible genes as determined by microarray analysis of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA)

Accession numbers

Full name

Symbol

Folds increased


NM_000584.2

interleukin 8

IL8

509.5

NM_004591.1

chemokine (C-C motif) ligand 20

CCL20

382.0

NM_002993.2

chemokine (C-X-C motif) ligand 6

CXCL6

314.1

NM_000600.1

interleukin 6

IL6

120.6

NM_001511.1

chemokine (C-X-C motif) ligand 1

CXCL1

88.6

NM_007115.2

tumor necrosis factor, alpha-induced protein 6

TNFAIP6

21.1

NM_002089.1

chemokine (C-X-C motif) ligand 2

CXCL2

20.4

NM_002982.3

chemokine (C-C motif) ligand 2

CCL2

20.0

NM_005623.2

chemokine (C-C motif) ligand 8

CCL8

17.5

NM_002421.2

matrix metallopeptidase 1

MMP1

16.1

NM_001078.2

vascular cell adhesion molecule 1

VCAM1

15.2

NM_000201.1

intercellular adhesion molecule 1

ICAM1

9.3

NM_001565.1

chemokine (C-X-C motif) ligand 10

CXCL10

8.2

NM_001012632.1

interleukin 32

IL32

4.3

NM_002006.3

fibroblast growth factor 2

FGF2

2.7


Bead array gene expression analysis of FLSs and IL-17 activated FLSs from patients with RA (RA FLS) at 12 h. After serum starvation for 24 h, the RA FLSs were stimulated with IL-17A (20 ng/ml) or without IL-17A. Total RNA from RA FLSs was used for the Bead array gene expression analysis. The genes differentially expressed between the IL-17 activated RA FLSs and the RA FLSs were identified by ANOVA with a P-value < 0.01.

Moon et al. Arthritis Research & Therapy 2012 14:R246   doi:10.1186/ar4089

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