Table 1 |
||||
|
Associations between systemic lupus erythematosus (SLE)-related serologic and clinical features and titer of progranulin (PGRN) |
||||
|
Feature |
Number |
Mean PGRN (95% confidence interval) |
P |
|
|
|
||||
|
Positivea |
Negativea |
|||
|
|
||||
|
Serologic featureb |
Positive/negative |
|||
|
Anti-Sm |
25/17 |
111.8 (93.4-130.1) |
94.1 (56.5-131.7) |
0.381c |
|
Anti-nRNP |
23/12 |
128.9 (102.7-155.0) |
74.9 (53.5-96.3) |
0.002c |
|
Anti-Ro |
26/13 |
102.7 (79.6-125.8) |
105.6 (67.6-143.6) |
0.888 |
|
Anti-CL |
20/24 |
112.4 (84.0-140.8) |
87.4 (65.2-109.6) |
0.150 |
|
Clinical featuresd |
||||
|
0 |
22 |
51.3 (34.5-68.1) |
<0.001ef |
|
|
1-2 |
31 |
91.8 (81.1-102.5) |
<0.001e |
|
|
3-8 |
15 |
132.3 (113.1-151.5) |
0.005g |
|
|
|
||||
|
anti-Sm, anti-Smith antibody; anti-nRNP, anti-ribonucleoprotein antibody; anti-Ro, anti-Ro/SS-A antibody; anti-CL, anti-cardiolipin antibody. aSLE patients with (present) or without (absent) the clinical features of SLE. bSeveral observations with missing values. cWelch t test. dNumber of positive clinical features including malar rash/discoid rash, alopecia, oral or nasal ulcers, serositis, arthritis, active nephritis, CNS (central nervous system) lupus, vasculitis, temperature >38°C, thrombocytopenia, leukopenia, anemia. eAs compared with three to eight clinical features (one-way analysis of variance followed by the Bonferroni test). fAs compared with one to two clinical features (one-way analysis of variance followed by the Bonferroni test). gP for trend. |
||||
|
Tanaka et al. Arthritis Research & Therapy 2012 14:R244 doi:10.1186/ar4087 |
||||
