Table 1

Associations between systemic lupus erythematosus (SLE)-related serologic and clinical features and titer of progranulin (PGRN)

Feature

Number

Mean PGRN (95% confidence interval)

P


Positivea

Negativea


Serologic featureb

Positive/negative

Anti-Sm

25/17

111.8 (93.4-130.1)

94.1 (56.5-131.7)

0.381c

Anti-nRNP

23/12

128.9 (102.7-155.0)

74.9 (53.5-96.3)

0.002c

Anti-Ro

26/13

102.7 (79.6-125.8)

105.6 (67.6-143.6)

0.888

Anti-CL

20/24

112.4 (84.0-140.8)

87.4 (65.2-109.6)

0.150

Clinical featuresd

0

22

51.3 (34.5-68.1)

<0.001ef

1-2

31

91.8 (81.1-102.5)

<0.001e

3-8

15

132.3 (113.1-151.5)

0.005g


anti-Sm, anti-Smith antibody; anti-nRNP, anti-ribonucleoprotein antibody; anti-Ro, anti-Ro/SS-A antibody; anti-CL, anti-cardiolipin antibody. aSLE patients with (present) or without (absent) the clinical features of SLE. bSeveral observations with missing values. cWelch t test. dNumber of positive clinical features including malar rash/discoid rash, alopecia, oral or nasal ulcers, serositis, arthritis, active nephritis, CNS (central nervous system) lupus, vasculitis, temperature >38°C, thrombocytopenia, leukopenia, anemia. eAs compared with three to eight clinical features (one-way analysis of variance followed by the Bonferroni test). fAs compared with one to two clinical features (one-way analysis of variance followed by the Bonferroni test). gP for trend.

Tanaka et al. Arthritis Research & Therapy 2012 14:R244   doi:10.1186/ar4087

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