Serum progranulin (PGRN) levels are significantly decreased after ameliorating the disease with treatment. Serum PGRN levels before and after treatment in 15 patients with active systemic lupus erythematosus (SLE) who had serum PGRN levels >80 ng/ml at the initial evaluation. The serum PGRN levels decreased significantly with the clinical amelioration of the disease from the median SLEDAI score of 11 to 4 after treatment.
Tanaka et al. Arthritis Research & Therapy 2012 14:R244 doi:10.1186/ar4087