Table 1

Effects of 1,000 μmol/l sodium ferulate on apoptosis-related gene expression in rat osteoarthritis chondrocytes.

Gene

Model control/normal control (20 ng/ml vs. 0 ng/ml IL-1β)

SF treatment/model control (1,000 μmol/l vs. 0 μmol/l SF in presence of 20 ng/ml IL-1β)


TNF/TNFR pathway

TNF

30.07

0.64

TNFR-1b

3.04

0.39

TRAF-2

2.50

0.43

TRADD

1.98

0.69

Caspase-8

2.30

0.43

Caspase-3

1.88

0.46

NF-κB

2.55

0.56

Other pathways

Fas

1.85

1.00

Fas ligand

0.45

0.42

FADD

0.94

0.58

Bcl-2

0.75

0.59

Bax

0.61

0.66

Bax/Bcl-2

0.80

1.12

Apaf1

0.76

1.03

Caspase 9

0.53

0.48


Each reported value represents the mean fold of mRNA expression relative to the control levels for three biological replicates. FADD, Fas-associated death domain protein; SF, sodium ferulate; TNFR, tumor necrosis factor receptor; TRADD, TNF receptor-associated death domain; TRAF, TNF receptor-associated factor.

Qin et al. Arthritis Research & Therapy 2012 14:R242   doi:10.1186/ar4085

Open Data