The genetic risk of developing rheumatoid arthritis (RA) conferred by a set of 28 Caucasian non-HLA susceptibility single-nucleotide polymorphisms is significantly different in the UK and in Africa. One thousand random samples of 43 RA cases and 163 controls (corresponding to the sample size of the African dataset) were generated out of a UK dataset comprising 5,024 RA cases and 4,281 controls. The distribution of odds ratios for association between the Caucasian genetic risk score (GRS) and disease susceptibility is shown in yellow for Caucasian random samples and in red for Africans.
Viatte et al. Arthritis Research & Therapy 2012 14:R239 doi:10.1186/ar4082