Table 2

Genes with concordant progression patterns in human and mouse disease

Progression

GeneSymbol

corHuman

p.Human

corMouse

p.Mouse

MM.magenta

+

ADA

0.57

5.5 × 10^-7

0.62

9.2 × 10^-4

0.70

+

AIF1

0.51

1.6 × 10^-5

0.57

3.1 × 10^-3

0.67

+

C1QB

0.54

3.2 × 10^-6

0.65

4.6 × 10^-4

0.71

+

CASP3

0.59

1.8 × 10^-7

0.52

8.2 × 10^-3

0.59

+

CYBB

0.63

1.6 × 10^-8

0.56

3.4 × 10^-3

0.82

+

ENTPD1

0.51

1.2 × 10^-5

0.62

8.5 × 10^-4

0.66

+

GZMA

0.63

1.7 × 10^-8

0.70

1.0 × 10^-4

0.72

+

GZMK

0.61

5.8 × 10^-8

0.55

4.1 × 10^-3

0.63

+

HLA-DQB1

0.53

6.0 × 10^-6

0.65

5.0 × 10^-4

0.48

+

HLA-DRB1

0.53

5.9 × 10^-6

0.74

2.6 × 10^-5

0.89

+

IFIT1

0.59

2.6 × 10^-7

0.59

1.9 × 10^-3

0.43

+

ITGAX

0.51

1.2 × 10^-5

0.63

6.8 × 10^-4

0.68

+

LY86

0.58

4.4 × 10^-7

0.53

6.4 × 10^-3

0.78

+

PLEKHA2

0.63

1.5 × 10^-8

0.52

7.1 × 10^-3

0.87

+

STAT1

0.67

7.2 × 10^-10

0.64

5.2 × 10^-4

0.60

+

TLR7

0.63

1.6 × 10^-8

0.63

6.6 × 10^-4

0.61

-

ALDH3A2

-0.50

1.8 × 10^-5

-0.63

8.0 × 10^-4

-0.64

-

ANGPTL4

-0.50

1.9 × 10^-5

-0.58

2.6 × 10^-3

-0.40

-

ATP1B1

-0.56

1.0 × 10^-6

-0.58

2.5 × 10^-3

-0.62

-

CPT1A

-0.54

4.0 × 10^-6

-0.76

8.7 × 10^-6

-0.55

-

FAF1

-0.54

4.1 × 10^-6

-0.55

4.5 × 10^-3

-0.58

-

NEO1

-0.52

9.6 × 10^-6

-0.53

6.9 × 10^-3

-0.47

-

PALMD

-0.50

2.2 × 10^-5

-0.64

6.1 × 10^-4

-0.65

-

PDHA1

-0.58

3.9 × 10^-7

-0.63

8.0 × 10^-4

-0.71

-

PPFIBP2

-0.56

1.2 × 10^-6

-0.57

3.2 × 10^-3

-0.48

corHuman denotes the correlation of the gene with human progression status (defined as 0 for controls, 1 for sicca, and 2 for primary Sjögren's syndrome). corMouse denotes the correlation of the gene with mouse progression status (weeks). p.Human and p.Mouse report the correlation test P values in human and mouse data, respectively. MM.magenta reports the module membership value of the gene.

Horvath et al. Arthritis Research & Therapy 2012 14:R238   doi:10.1186/ar4081