Identification of primary Sjögren's syndrome disease-related gene modules revealed by weighted gene co-expression network analysis. Barplots showing the mean value of the module eigengene (y axis) versus human disease progression status (x axis) where 0 denotes healthy controls, 1 denotes nonprimary Sjögren's syndrome (non-pSS) sicca patients, and 2 denotes pSS patients. Kruskal-Wallis test P values above the plots show that the module eigengenes of all four modules - Magenta (576 genes), Brown (2,502 genes), Grey60 (216 genes), and Light-Cyan (349 genes) - are significantly overexpressed in pSS patients compared with both non-pSS sicca patients and controls.
Horvath et al. Arthritis Research & Therapy 2012 14:R238 doi:10.1186/ar4081