Figure 1.

Structure of Y27 and its effect on CD4⁺CD25⁺ regulatory T (Treg) cells. (A) Structure of Y27. (B) Structure of H1521. (C) Y27 concentration-dependent enhancement of the suppressive capacity of CD4⁺CD25⁺ Treg cells in C57BL/6 mice in vitro. Suppressive activity of CD4⁺CD25⁺ Treg cells was expressed as percent suppression calculated as following: 100 × (cpm (CD4⁺CD25^- Tconv) - cpm (CD4⁺CD25^- Tconv + CD4⁺CD25⁺ Treg))/cpm (CD4⁺CD25^- Tconv). Tconv, conventional CD4⁺CD25^- effector T cells.