Table 1

Main studies addressing the histopathologic picture of subchondral bone marrow involvement in rheumatoid arthritis

Number of samples

Disease duration*

Site of surgery

MRI

Main findings


Jimenez-Boj et al. [39]

12 (12 pts)

18.9 (± 2.8)

10 small joints, 1 wrist, 1 large joint

-

Lymphocytic aggregates with predominance of B cells (immunohistochemistry)

Bugatti et al. [38]

8 (8 pts)

12.5 (± 8.8)

2 small joints, 1 wrist, 5 large joints

-

Lymphocytic aggregates (immunohistochemistry)

Kuca-Warnawin et al. [23]

6 (6 pts)

-

6 large joints

-

Lymphocytic aggregates (immunohistochemistry)

Jimenez-Boj et al. [35]

12 (3 pts)

15.3 (± 8.1)

12 small joints

Available

Infiltration of hematopoietic cells, lymphocytic aggregates, blood vessels (histology)

McQueen et al. [36]

7(4 pts)

27 (± 11.7)

7 small joints

Available

Lymphoplasmacytic infiltration, focal necrosis, fibrosis (histology)

Dalbeth et al. [37]

28 (11 pts)

21 (± 9.6)

23 small joints, 2 wrists, 3 ankles

Available

Infiltration of macrophages, plasma cells, CD8+ T cells, B cells (immunohistochemistry)

Total

73 (44 pts)

54 small joints (hands/feet), 7 wrists/ankles, 12 large joints (knee/hip)


*Data given as mean (± SD) years. Pts, patients.

Bugatti et al. Arthritis Research & Therapy 2012 14:229   doi:10.1186/ar4115