Table 1

Classification of histone deacetylases and their inhibitors

Class

Member

Inhibitors

References


I

HDAC1

TSA, SAHA, ITF2357, FK228, VPA, MS-275

[27,40,47-51]

HDAC2

TSA, SAHA, ITF2357, FK228, VPA

HDAC3

TSA, SAHA, ITF2357, FK228, VPA, MS-275, MI192

HDAC8

TSA, SAHA, ITF2357, FK228, VPA

II

HDAC4

TSA, SAHA, ITF2357, VPA

[27,47,49,50]

HDAC5

TSA, SAHA, ITF2357, VPA

HDAC6

TSA, SAHA, ITF2357, VPA

HDAC7

TSA, SAHA, ITF2357, VPA

HDAC9

TSA, SAHA, ITF2357, VPA

HDAC10

TSA, SAHA, ITF2357, VPA

III

SIRT1 to SIRT7

Nicotinamide

[52]

IV

HDAC11

-


Human histone deacetylases (HDACs) were classified into four subgroups. HDAC inhibitors summarized in the text are listed. SAHA, suberoylanilide hydroxamic acid; SIRT, sirtuin; TSA, trichostatin A; VPA, valproic acid.

Klein et al. Arthritis Research & Therapy 2012 14:227   doi:10.1186/ar4074