Table 2

Microarray gene expression of soleus muscle-fiber energy metabolism and gene products involved in fiber-type regulation

Gene description (gene symbol)

FC

P value

q value


Respiratory chain complex I


NADH dehydrogenase (ubiquinone) 1α subcomplex, 4 (Ndufa4)

-1.1

0.007

0.999

NADH dehydrogenase (ubiquinone) 1α/β subcomplex, 1 (Ndufab1)

1.0

0.507

0.999

NADH dehydrogenase (ubiquinone) 1α subcomplex, assembly factor 1 (Ndufaf1)

-1.1

0.110

0.999

NADH dehydrogenase (ubiquinone) 1β subcomplex 3 (Ndufb3)

-1.0

0.772

0.999

NADH dehydrogenase (ubiquinone) 1β subcomplex, 5 (Ndufb5)

-1.1

0.036

0.999

NADH dehydrogenase (ubiquinone) 1 β subcomplex, 9 (Ndufb9)

-1.0

0.286

0.999

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 (Ndufc1)

-1.1

0.167

0.999

NADH dehydrogenase (ubiquinone) Fe-S protein 1 (Ndufs1)

-1.1

0.045

0.999

NADH dehydrogenase subunit 1 (mt-ND1)

-1.1

0.267

0.999

NADH dehydrogenase subunit 2 (mt-ND2)

-1.1

0.087

0.999

NADH dehydrogenase subunit 4L (mt-ND4l)

-1.1

0.004

0.999

NADH dehydrogenase subunit 5 (mt-ND5)

-1.1

0.002

0.999

NADH dehydrogenase subunit 6 (mt-ND6)

-1.2

0.364

0.999


Respiratory chain complex II


Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb)

-1.4

0.00001

0.139


Respiratory chain complex III


Ubiquinol-cytochrome c reductase binding protein (Uqcrb)

-1.1

0.003

0.999

Ubiquinol-cytochrome c reductase core protein I (Uqcrc1)

-1.0

0.677

0.999

Ubiquinol cytochrome c reductase core protein 2 (Uqcrc2)

-1.1

0.039

0.999


Respiratory chain complex IV


Cytochrome c oxidase, subunit Va (Cox5a)

-1.1

0.205

0.999

Cytochrome c oxidase subunit Vb (Cox5b)

-1.0

0.442

0.999

Cytochrome c oxidase, subunit VIa, polypeptide 2 (Cox6a2)

-1.1

0.096

0.999

Cytochrome c oxidase, subunit VIc (Cox6c)

-1.1

0.144

0.999

Cytochrome c oxidase subunit VIIb (Cox7b)

1.0

0.501

0.999

Cytochrome c oxidase, subunit VIIa 2 (Cox7a2)

-1.1

0.006

0.999

Cytochrome c oxidase subunit VIIa polypeptide 2 like (Cox7a2l)

-1.2

0.002

0.999

Cytochrome c oxidase subunit I (mt-Co1)

-1.1

0.000

0.999

Cytochrome c oxidase subunit II (mt-Co2)

-1.1

0.028

0.999


Respiratory chain complex V


ATP synthase, F1 complex, γ polypeptide 1 (Atp5c1)

1.0

0.807

0.999

ATP synthase, F0 complex, subunit C3 (subunit 9) (Atp5g3)

-1.1

0.080

0.999

ATP synthase GA binding protein transcription factor, α subunit: (Gabpa: Atp5j)

-1.2

0.005

0.999

ATP synthase, F0 complex, subunit F2 (Atp5j2)

1.0

0.548

0.999

ATP synthase F0 subunit 6 (mt-atp6)

-1.3

0.739

0.999

ATP synthase F0 subunit 8 (mt-atp8)

-1.1

0.016

0.999


Glycolysis


Phosphofructokinase, muscle (Pfkm)

2.1

1.00E-35

1.00E-35

Pyruvate kinase, muscle (Pkm2)

2.7

1.00E-35

1.00E-35

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3)

2.9

1.19E-13

3.26E-09


Glycogenolysis


Phosphorylase, glycogen, muscle (Pygm)

1.3

1.78E-14

4.88E-10

Phosphoglucomutase 1 (Pgm1)

2.8

1.00E-35

1.00E-35

Phosphoglucomutase 2-like 1 (Pgm2l1)

2.2

1.19E-13

3.25E-09


Fatty acid ß-oxidation


Carnitine palmitoyltransferase 1b, muscle (CPT1b)

-1.4

3.52E-07

0.009

Hydroxyacyl-Coenzyme A dehydrogenase (Hadh)

-1.6

2.02E-07

0.005


Regulator genes (muscle fiber-type switch)


SRY (sex-determining region Y)-box 6 (Sox6)

5.2

1.00E-35

1.00E-35

Myogenic differentiation 1 (Myod1)

4.4

1.11E-16

3.06E-12

Myogenin (Myog)

-3.7

1.78E-09

4.82E-05

Regulator of calcineurin 1 (Rcan1)

-4.6

3.51E-13

9.61E-09

SIX homeobox 1 (Six1)

2.0

5.68E-12

1.55E-07

SIX homeobox 2 (Six2)

5.0

9.39E-13

2.57E-08

Myostatin (Mstn)

4.4

3.74E-13

1.03E-08

Estrogen-related receptor γ (Esrrg)

-2.1

1.07E-10

2.91E-06

NFAT activating protein with ITAM motif 1 (Nfam1)

-1.7

3.34E-08

8.96E-04


The fold-change (FC) value indicates the relative amounts of transcripts in rats treated with zidovudine, compared with control animals. The Benjamini Hochberg q value indicates the false-discovery rate.

Venhoff et al. Arthritis Research & Therapy 2012 14:R233   doi:10.1186/ar4076

Open Data