|
Resolution: standard / high Figure 9.
Adiponectin suppresses fibrotic responses. Ligands of PPAR-γ induce adiponectin which triggers autocrine or paracrine activation
of AMP kinase. AMP kinase in turn blocks TGF-β/Smad signaling and consequent stimulation
of profibrotic gene expression. PPAR-γ, peroxisome proliferator activated receptor
gamma; TGF-β, transforming growth factor-β.
Fang et al. Arthritis Research & Therapy 2012 14:R229 doi:10.1186/ar4070 |
