Regulation of DKK1 expression by glucocorticoids. (A) Time course for induction of DKK1 protein expression by synovial fibroblasts (FLS) in response to dexamethasone or TNFα. (B) Dose response curves for the secretion of DKK1 in response to dexamethasone (expressed relative to baseline expression). *P < 0.05, **P < 0.01 relative to control.
Hardy et al. Arthritis Research & Therapy 2012 14:R226 doi:10.1186/ar4065