Percentage changes in serum C- terminal propeptide of type I procollagen (PICP) at 6, 12 and 18 months after the start of treatment in the bisphosphonate (Bis) and Bis + statin groups. A significant increase in serum PICP was observed at 6 months in the Bis and Bis + statin group. On the other hand, in the Bis + statin group serum PICP tends to increase after 12 months. *P < 0.05, **P < 0.01, for comparison to baseline for each group.
Nagashima et al. Arthritis Research & Therapy 2012 14:R224 doi:10.1186/ar4063