Percentage changes in serum tartrate-resistant acid phosphate-5b (TRACP-5b) at 6, 12 and 18 months after the start of treatment in the bisphosphonate (Bis) and Bis + statin groups. Circles represent the Bis group and triangles represent the Bis + statin group. Significant increases in serum TRACP-5b were observed at 6, 12 and 18 months in the Bis + statin group, but in the Bis group a significant increase was only observed at 18 months. *P < 0.05, *P < 0.01, ***P < 0.001, for comparison to baseline for each group.
Nagashima et al. Arthritis Research & Therapy 2012 14:R224 doi:10.1186/ar4063