Percentage changes in serum N-terminal telopeptide of type I collagen (NTX) at 6, 12 and 18 months after the start of treatment in the bisphosphonate (Bis) and Bis + statin groups. Circles represent the Bis group and triangles represent the Bis + statin group. A significant decrease in serum NTX was observed at 12 months in the Bis group, but in the Bis + statin group, serum NTX was up-regulated during the follow-up period except at 6 months. *P < 0.05, **P < 0.01, for comparison to baseline for each group.
Nagashima et al. Arthritis Research & Therapy 2012 14:R224 doi:10.1186/ar4063