Percentage changes in bone mineral density (BMD) of the lumbar spine measured by dual-energy x-ray absorptiometry (DXA) at 6, 12 and 18 months after the start of treatment in the bisphosphonate (Bis) and Bis + statin groups. Circles represent the Bis group and triangles represent the Bis + statin group. Significant increases in BMD of the lumbar spine were observed at 6, 12 and 18 months in the Bis + statin group, but in the Bis group a significant increase was only observed at 18 months. *P < 0.05, **P < 0.01, ***P < 0.001, for comparison to baseline for each group.
Nagashima et al. Arthritis Research & Therapy 2012 14:R224 doi:10.1186/ar4063