Open Access Highly Accessed Research article

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation

Benjamin Terrier1,2,3, Nicolas Derian1,2, Yoland Schoindre4, Wahiba Chaara1,2,5, Guillaume Geri1,2,3, Noël Zahr6, Kubéraka Mariampillai7, Michelle Rosenzwajg1,2,3,5, Wassila Carpentier8, Lucile Musset9, Jean-Charles Piette7, Adrien Six1,2,5, David Klatzmann1,2,3,5, David Saadoun1,2,3,7, Cacoub Patrice1,2,3,7 and Nathalie Costedoat-Chalumeau1,2,3,7*†

1 UPMC Université Paris 6, UMR 7211, F-75013 Paris, France

2 Centre National de la Recherche Scientifique (CNRS), UMR 7211, Paris, France

3 INSERM, UMRS959; Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

4 Department of Internal Medicine, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France

5 Department of Biotherapy, Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

6 Department of Pharmacology, Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

7 Department of Internal Medicine, Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

8 P3S post-genomic platform, Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

9 Department of Immunology, Groupe Hospitalier Pitié-Salpétrière, 47 boulevard de l'Hôpital, 75013 Paris, France

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Arthritis Research & Therapy 2012, 14:R221 doi:10.1186/ar4060

Published: 17 October 2012

Additional files

Additional file 1:

Microarray gene expression profile analysis. This file contains additional material and a methods section that describes microarray gene expression profile analysis, and Figure S1 that illustrates clustering analysis of significant modulated signatures in patients at month 2 compared to baseline.

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