Table 4

MOS-Sleep Scale scores at baseline and final assessment

Assessment

Baseline mean score ± SD

Final assessment LS mean score ± SE

Placebo-adjusted LS mean change from baseline with pregabalina


Placebo

Pregabalin

Placebo

Pregabalin

Change

95% CI

P-value


Sleep disturbanceb

47.7 ± 26.1

48.0 ± 26.5

39.76 ± 1.31

30.27 ± 1.31

-9.48

-13.12, -5.85

<0.0001*

Sleep adequacy

29.0 ± 23.7

28.7 ± 24.5

36.91 ± 1.41

44.39 ± 1.40

7.48

3.58, 11.38

<0.0001*

Quantity of sleep

5.4 ± 1.4

5.6 ± 1.3

5.70 ± 0.06

5.99 ± 0.06

0.29

0.11, 0.47

0.0007*

Awakening short of breath/headache

25.8 ± 26.6

26.2 ± 26.1

22.99 ± 1.36

18.00 ± 1.36

-4.99

-8.77, -1.21

0.0049*

Snoring

26.5 ± 28.7

25.0 ± 28.1

24.19 ± 1.33

29.17 ± 1.33

4.98

1.29, 8.68

0.9958

Somnolence

41.6 ± 23.3

40.5 ± 24.3

36.41 ± 1.29

47.71 ± 1.28

11.31

7.74, 14.87

1.0000

Overall sleep problems index

49.8 ± 17.2

49.7 ± 18.5

42.66 ± 0.96

39.67 ± 0.95

-2.99

-5.65, -0.33

0.0137*


aDifference in mean change from baseline, compared with placebo using the baseline score as covariate. bMOS-Sleep Scale subscales scored from 0 to 100 with higher scores indicating more of the attribute named in the subscale except for 'quantity of sleep', scored from 0 to 24 indicating the number of hours of sleep.

*Indicates statistical significance at the P <0.025 level.

CI, confidence interval; LS, least squares; MOS, Medical Outcomes Study; SD, standard deviation; SE, standard error

Ohta et al. Arthritis Research & Therapy 2012 14:R217   doi:10.1186/ar4056

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