Table 2

AS baseline parameters considered as predictors of anti-TNF response and persistent inflammation (CRP ≥ 5 mg/L) at 12 months

Baseline parameters

CRP ≥ 5 mg/L

n = 10

CRP < 5 mg/L

n = 20

P


Age, years

31.6 ± 10.8

37.7 ± 10.8

0.157

Disease duration, years

10.6 ± 8.9

12.5 ± 9.4

0.598

mSASSS

16.5 ± 14.9

23.35 ± 19.0

0.329

BMD lumbar spine, g/cm2

1.020 ± 0.191

1.040 ± 0.168

0.771

BASDAI

4.89 ± 2.1

5.56 ± 2.2

0.415

C-reactive protein, mg/L

58.13 ± 71.1

26.5 ± 27.4

0.166

ESR, mm/hr

38.5 ± 34.9

16.7 ± 9.8

0.176

MMP-3, ng/mL

70.2 ± 52.3

37.8 ± 33.0

0.090

Sclerostin, pmol/L

41.4 ± 19.5

70.0 ± 33.3

0.023


Values are expressed as mean (SD). AS, ankylosing spondylitis; mSASSS, modified Stoke Ankylosing Spondylitis Spine Score; BMD, bone mineral density; BASDAI, Bath AS Disease Activity Index; ESR, erythrocyte sedimentation rate; MMP-3, matrix metalloproteinase 3.

Saad et al. Arthritis Research & Therapy 2012 14:R216   doi:10.1186/ar4055

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