Table 2

Relation of CRP genotypes to baseline CRP levels

SNP

HWE (p)

Genotype

Geometric mean CRP (mg/L) (SD)

n

P value


rs1205

0.60

GG

32.17 (2.75)

272

Ref.

GA

31.51 (2.67)

270

0.81

AA

26.39 (2.70)

57

0.17

rs1800947†

0.23

CC

31.93 (2.70)

533

Ref.

CG

26.47 (2.76)

66

0.15

rs3091244_T

0.33‡

XX

29.09 (2.73)

278

Ref.

XT

34.40 (2.72)

261

0.05

TT

28.94 (2.53)

60

0.97

rs3091244_A¶

XX

31.36 (2.70)

550

Ref.

XA

30.32 (2.68)

33

0.85


SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg Expectation; SD, standard copies of T allele. For the A allele of rs3091244: XX, no copies of A allele; XA one copy of A allele; AA two copies of A allele.

† No homozygote minor allele observed in this dataset.

‡ rs3091244_T & rs3091244_A SNPs combined to give HWE of rs3091244.

¶ Homozygote minor alleles grouped with heterozygotes.

Plant et al. Arthritis Research & Therapy 2012 14:R214   doi:10.1186/ar4052

Open Data