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Open Access Highly Accessed Research article

TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation

Hye Sung Kim12 and Doo Hyun Chung12*

Author Affiliations

1 Department of Pathology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea

2 Laboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea

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Arthritis Research & Therapy 2012, 14:R210  doi:10.1186/ar4048

Published: 4 October 2012

Additional files

Additional file 1:

Subset analysis for joint cells from mice with antibody-induced arthritis. Total joint cells were obtained from WT mice seven days after K/BxN serum transfer and analyzed for cell subsets. (A) Total cells were stained using anti-CD45.2 mAb as compared with isotype-matched control. (B) Subset analysis for total joint cells was performed.

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