Table 1

Patient demographics and clinical data

Synovia

Nodules

Smokers(n = 6*)

Non-smokers(n = 11*)

Smokers(n = 4)

Non-smokers(n = 14)


Female, %

83

64

100

71

Age, years**

58 (37-79)

55 (35-74)

47 (44-50)

61(48-77)

Disease duration, years**

11 (2-30)

18 (3-30)

19 (13-30)

19 (2-44)

Nodules, n

5 (83%)

9 (82%)

4 (100%)

14 (100%)

Erosions, n

6 (100%)

10 (91%)

4 (100%)

13 (93%)

RF positive, n

6 (100%)

10 (91%)

4 (100%)

13 (93%)

ACPA Positive, n/total ACPA Titer††

5/5 (100%)

157 ± 45

8/9 (89%)

177 ± 26

4/4 (100%)

193 ± 57

12/13 (92%)

157 ± 22

ESR**

34 (3-85)

33 (13-64)

30 (13-64)

33 (6-54)


* Three patients (one smoker, two non-smokers) provided two synovial samples. ** mean values with the range in parenthesis. For some patients, tissue samples pre-dated the availability of tests for anticitrullinated peptide antibody (ACPA); †† Mean values ± SEM. Mean ACPA titers were not significantly different. n, number of patients; RF, rheumatoid factor; SEM, standard error of the mean,]; ESR, erythrocyte sedimentation rate.

Kazantseva et al. Arthritis Research & Therapy 2012 14:R208   doi:10.1186/ar4046

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