Additional file 1.

Long-term effect of smoking on aryl hydrocarbon receptor (AHR) expression and activation in synovial tissues. Shown is any effect from current smoking or former smoking on AHR expression and CYP1A1 gene expression in joint synovial tissue from RA patients. Comparisons are made with data from non-smokers. There is no significant difference in synovial AHR expression between RA patients who are current smokers, ex-smokers or non-smokers. The expression of CYP1A1, reflecting AHR activation, is significantly different only in rheumatoid arthritis (RA) patients who continue to smoke.

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Kazantseva et al. Arthritis Research & Therapy 2012 14:R208   doi:10.1186/ar4046