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Open Access Highly Accessed Research article

Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis

Marina G Kazantseva1, John Highton2, Lisa K Stamp3 and Paul A Hessian1*

Author Affiliations

1 Department of Physiology, University of Otago, P.O. Box 913, Dunedin 9054, NZ

2 Department of Medicine, University of Otago, P.O. Box 913, Dunedin 9054, NZ

3 Department of Medicine, University of Otago, P.O. Box 4345, Christchurch 8041, NZ

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Arthritis Research & Therapy 2012, 14:R208  doi:10.1186/ar4046

Published: 4 October 2012

Additional files

Additional file 1:

Long-term effect of smoking on aryl hydrocarbon receptor (AHR) expression and activation in synovial tissues. Shown is any effect from current smoking or former smoking on AHR expression and CYP1A1 gene expression in joint synovial tissue from RA patients. Comparisons are made with data from non-smokers. There is no significant difference in synovial AHR expression between RA patients who are current smokers, ex-smokers or non-smokers. The expression of CYP1A1, reflecting AHR activation, is significantly different only in rheumatoid arthritis (RA) patients who continue to smoke.

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