Table 3

Baseline cytokine expression of nasal epithelial cells (pg/ml)

Normal control (NC)

Granulomatosis with polyangiitis (GPA)

NC vs. GPA

median

range

median

range

P-value

IL- 1α

71.74

<1.51 to 319.24

92.38

7.90 to 477.11

0.322

IL-1β

<2.67

<2.67 to 8.67

2.70

<2.67 to 12.74

0.224

IL-2

<1.42

<1.42 to 6.46

3.60

<1.42 to 6.00

0.070

IL-4

<0.32

<0.32 to 0.80

<0.32

<0.32 to 0.72

0.283

IL-5

below detection limit (<2.51)

IL-6

26.22

2.81 to 788.29

29.61

3.70 to 139.47

0.607

IL-7

below detection limit (<2.43)

IL-8

1388.14

<1.77 to 5188.14

319.16

<1.77 to 3708.72

0.009

IL-10

below detection limit (<1.78)

IL-12

<2.55

<2.55 to 3.75

<2.55

<2.55 to 4.03

0.283

IL-13

below detection limit (<2.68)

IL-17

2.77

<1.87 to 6.41

3.54

<1.87 to 6.01

0.101

G-CSF

19.60

<1.31 to 204.41

61.30

1.53 to 663.58

0.050

GM-CSF

10.50

<0.74 to 28.70

12.50

7.74 to 21.56

0.084

IFN-γ

4.61

<1.61 to 21.41

5.92

2.27 to 18.18

0.089

MCP-1

3.66

<1.81 to 8.21

4.12

<1.81 to 7.90

0.667

MIP-1β

<1.41

<1.41 to 2.37

1.43

<1.41 to 2.79

0.141

TNF-α

<6.42

<6.42 to 13.46

<6.42

<6.42 to 11.00

0.296

TNF-β

9.44

<2.14 to 24.46

14.20

3.35 to 23.40

0.054

Wohlers et al. Arthritis Research & Therapy 2012 14:R203   doi:10.1186/ar4041