Effect of stimulation with S. aureus. Significant differences in IL-8 expression of primary nasal epithelial cells (NEC) comparing granulomatosis with polyangiitis (GPA) patients and normal controls (NC) before and after stimulation with S. aureus supernatants (A, P = 0.006). Furthermore, the dynamic range (Δ IL-8, secretion after stimulation minus basal secretion) is significantly reduced in GPA-patients (B, P = 0.029).
Wohlers et al. Arthritis Research & Therapy 2012 14:R203 doi:10.1186/ar4041