Table 3 |
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|
Reproducibility of US endpoints. |
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|
10 MCP US endpoint |
Reproducibility method |
Baseline ICC (95% CI) |
Day 15 ICC (95% CI) |
|
|
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|
Long PDA |
Within-scan inter-reader |
0.89 (0.80; 0.99) |
0.98 (0.95; 1.00) |
|
Parallel scan intra-reader |
0.80 (0.64; 0.96) |
0.62 (0.36; 0.88) |
|
|
Parallel scan inter-reader |
0.78 (0.59; 0.97) |
0.68 (0.45; 0.92) |
|
|
Long STA |
Within-scan inter-reader |
0.76(0.56; 0.95) |
0.81 (0.65; 0.97) |
|
Parallel scan intra-reader |
0.95 (0.90; 1.00) |
0.83 0.68; 0.98) |
|
|
Parallel scan inter-reader |
0.85 (0.72; 0.98) |
0.71 (0.48; 0.95) |
|
|
Long STi |
Within-scan inter-reader |
0.67 (0.40; 0.93) |
0.54 (0.20; 0.88) |
|
Parallel scan intra-reader |
0.87 (0.75; 0.99) |
0.82 (0.66; 0.98) |
|
|
Parallel scan inter-reader |
0.67 (0.42; 0.93) |
0.46 (0.07; 0.85) |
|
|
Long VASCi |
Within-scan inter-reader |
0.90 (0.81; 0.99) |
0.94 (0.88; 1.00) |
|
Parallel scan intra-reader |
0.93 (0.87; 0.99) |
0.94 (0.88; 1.00) |
|
|
Parallel scan inter-reader |
0.83 (0.67; 0.98) |
0.85 (0.72; 0.99) |
|
|
Trans PDA |
Within-scan inter-reader |
0.99 (0.98; 1.00) |
1.00 (0.99; 1.00) |
|
Parallel scan intra-reader |
0.75 (0.57; 0.93) |
0.76 (0.57; 0.94) |
|
|
Parallel scan inter-reader |
0.72 (0.51; 0.93) |
0.75 (0.55; 0.96) |
|
|
Trans STA |
Within-scan inter-reader |
0.52 (0.33; 0.72) |
0.57 (0.36; 0.79) |
|
Parallel scan intra-reader |
0.83 (0.68; 0.98) |
0.92 (0.85; 0.99) |
|
|
Parallel scan inter-reader |
0.57 (0.24; 0.89) |
0.40 (0.01; 0.80) |
|
|
Trans STi |
Within-scan inter-reader |
0.48 (0.19; 0.76) |
0.36 (0.10; 0.62) |
|
Parallel scan intra-reader |
0.83 (0.68; 0.98) |
0.77 (0.58; 0.97) |
|
|
Parallel scan inter-reader |
0.00 (-0.46; 0.46) |
0.01 (-0.46; 0.48) |
|
|
Trans VASCi |
Within-scan inter-reader |
0.92 (0.84; 0.99) |
0.96 (0.92; 1.00) |
|
Parallel scan intra-reader |
0.73 (0.52; 0.94) |
0.91 (0.84; 0.99) |
|
|
Parallel scan inter-reader |
0.68 (0.45; 0.92) |
0.78 (0.60; 0.96) |
|
|
|
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|
ICC (intraclass correlation coefficient) values of <0.40, poor to fair agreement; 0.41 to 0.60, moderate agreement; 0.61 to 0.80, good agreement; and 0.81 to 1.00, excellent agreement. CI, confidence interval; PDA; Power Doppler Area; STA, synovial thickness area; STi, synovial thickness index; VASCi, vascularity index. |
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|
Seymour et al. Arthritis Research & Therapy 2012 14:R198 doi:10.1186/ar4034 |
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