Additional file 2.

Matrilin-3 (MATN3) stimulates type II collagen (COL2A1) mRNA levels for at least 24 hours in human chondrocytes. A figure showing that MATN3 induces COL2A1 mRNA levels in C28/I2 cells (A) and primary human chondrocytes (PHCs) (B) after 24 hours treatment. Recombinant human (rh) MATN3 protein is used at 200 ng/ml and rh IL-1β protein treatment is used at 5.0 ng/ml. *P ≤ 0.05 for statistically significant differences from the untreated control group; #P ≤ 0.05 for statistically significant differences from the IL-1β only treated group. Data are representative of three individual experiments.

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Jayasuriya et al. Arthritis Research & Therapy 2012 14:R197   doi:10.1186/ar4033