Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4'

Francesca Oliviero1*, Anna Scanu1, Jean-Michel Dayer2, Ugo Fiocco1, Paolo Sfriso1 and Leonardo Punzi1

Author affiliations

1 Department of Medicine, Rheumatology Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy

2 Faculty of Medicine, CMU, 1, rue Michel-Servet, CH-1211 Geneva, Switzerland

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Citation and License

Arthritis Research & Therapy 2012, 14:405  doi:10.1186/ar3863

See related research by Sohn et al., http://arthritis-research.com/content/14/1/R7, and related letter by Sohn et al., http://arthritis-research.com/content/14/5/406.

Published: 12 September 2012

First paragraph (this article has no abstract)

We read with great interest the article by Sohn and colleagues published in the February 2012 issue of Arthritis Research & Therapy [1]. Using proteomic analysis, the authors were able to show that plasma proteins present in osteoarthritic synovial fluid are able to induce inflammatory cytokine production via interaction with Toll-like receptor 4, thus contributing to the low-grade inflammation associated with osteoarthritis.