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Letter

Response to 'Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice'

Gn Kim and Think-You Kim*

Author affiliations

Department of Early Arthritis/Laboratory of Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, 133-792 Seoul, Republic of Korea

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Citation and License

Arthritis Research & Therapy 2012, 14:404  doi:10.1186/ar4023


See related research by Hsieh et al., http://arthritis-research.com/content/13/5/R162

Published: 10 September 2012

First paragraph (this article has no abstract)

We read with interest the recent paper by Hsieh and colleagues [1] asserting that cytomegalovirus (CMV) induces systemic lupus erythematosus (SLE) in genetically susceptible individuals. This assertion is based on the idea that SLE-associated autoantibodies that had been induced by a certain fragment of CMV were found in rodents. However, our previous studies have reported that autoantibodies detected in SLE and viral infection are different, especially with regard to the anti-microtubule organizing center with microtubule (anti-MTOC-MT) [2-4]. We conducted a retrospective study comparing autoantibodies in three groups: anti-CMV IgM-positive SLE patients (SLE-CMV group); anti-CMV IgM-positive patients without SLE (CMV group); and anti-CMV IgM-negative SLE patients (SLE group). This study was approved by the institutional review board of Hanyang University Medical Center.