Response to 'Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice'
Department of Early Arthritis/Laboratory of Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, 133-792 Seoul, Republic of Korea
Arthritis Research & Therapy 2012, 14:404 doi:10.1186/ar4023
See related research by Hsieh et al., http://arthritis-research.com/content/13/5/R162Published: 10 September 2012
First paragraph (this article has no abstract)
We read with interest the recent paper by Hsieh and colleagues  asserting that cytomegalovirus (CMV) induces systemic lupus erythematosus (SLE) in genetically susceptible individuals. This assertion is based on the idea that SLE-associated autoantibodies that had been induced by a certain fragment of CMV were found in rodents. However, our previous studies have reported that autoantibodies detected in SLE and viral infection are different, especially with regard to the anti-microtubule organizing center with microtubule (anti-MTOC-MT) [2-4]. We conducted a retrospective study comparing autoantibodies in three groups: anti-CMV IgM-positive SLE patients (SLE-CMV group); anti-CMV IgM-positive patients without SLE (CMV group); and anti-CMV IgM-negative SLE patients (SLE group). This study was approved by the institutional review board of Hanyang University Medical Center.