The IL-17R/Act1/TRAF protein complex. The extracellular IL-17R binds the IL-17 cytokines. Act1 proteins bind to the intra-cellular SEFIR motif, which is present on both of the receptors. The Act1 adaptor proteins contain TRAF motifs, which bind different TRAF proteins. Downstream progression leads to activation of pro-inflammatory genes. Act1, nuclear factor-kappa-B activator 1; IKK, IkB kinase; IL-17, interleukin-17; IL-17R, interleukin-17 receptor; NF-κB, nuclear factor-kappa-B; SEFIR, similar expression to fibroblast growth factor genes/interleukin-17 receptor; TAB, transforming growth factor-beta-activated kinase 1 (TAK1)-binding protein; TAK1, transforming growth factor-beta-activated kinase 1; TRAF, tumor necrosis factor receptor-associated factor.
Doyle et al. Arthritis Research & Therapy 2012 14:226 doi:10.1186/ar4071