The structure (exon/intron) of the TRAF3IP2/Act1 gene and the location of single-nucleotide polymorphisms from the genome-wide association study. The risk alleles are in bold. For each haplotype, odds ratios (ORs) (and 95% confidence intervals) compare the occurrence of the haplotype versus all three other alleles. The single-nucleotide polymorphisms (rs33980500 and rs13190932) occur within the N-terminal region of TRAF3IP2 (Figure 1). Reproduced with permission from Huffmeier and colleagues . Act1, nuclear factor-kappa-B activator 1; TRAF3IP2, tumor necrosis factor receptor-associated factor 3-interacting protein 2.
Doyle et al. Arthritis Research & Therapy 2012 14:226 doi:10.1186/ar4071