Ways forward to identify new ACPA targets in RA
Rheumatology Unit, Dept Of Medicine, CMM L8:04, Karolinska University Hospital Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden
Arthritis Research & Therapy 2012, 14:124 doi:10.1186/ar4031
See related research by Raijmakers et al., http://arthritis-research.com/content/14/3/R114Published: 24 September 2012
Anti-citrullinated protein antibodies (ACPAs) of the IgG subtype have become a critical hallmark of HLA-associated rheumatoid arthritis (RA) and point to important contributions from the adaptive immune system. To dissect the contributing autoimmune reactions, investigators must not only identify the protein targets of ACPA but also define the precise peptides recognized by the immune system. Several possible approaches could be used to achieve this goal, and sensitive mass spectrometry of relevant tissue is a promising way forward in advancing our detailed understanding of autoimmune immune reactions involved in RA pathogenesis.