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Volume 14 Issue 5
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Comment |
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Ways forward to identify new ACPA targets in RA
A Jimmy Ytterberg, Vivianne Malmström Arthritis Research & Therapy 2012, 14:124 (24 September 2012)
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4th International Forum on Rheumatoid Arthritis: Great Times Near the Great Wall
David S Pisetsky Arthritis Research & Therapy 2012, 14:125 (27 September 2012)
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Review |
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Common variable immunodeficiency - an update
Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012)
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Bone marrow edema and osteitis in rheumatoid arthritis: the imaging perspective
Fiona M McQueen Arthritis Research & Therapy 2012, 14:224 (28 September 2012)
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New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis
Matthew S Doyle, Emily S Collins, Oliver M FitzGerald, Stephen R Pennington Arthritis Research & Therapy 2012, 14:226 (31 October 2012)
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Research |
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Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression
Chathuraka T Jayasuriya, Mary B Goldring, Richard Terek, Qian Chen Arthritis Research & Therapy 2012, 14:R197 (11 September 2012)
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Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study
Matthew W Seymour, Stephen Kelly, Chan R Beals, Marie-Pierre Malice, James A Bolognese, Bernard J Dardzinski, Amy S Cheng, Corinne E Cummings, Steven S Smugar, Catherine McClinton, Amy Fox, William M Dooley, Constantino Pitzalis, Peter C Taylor Arthritis Research & Therapy 2012, 14:R198 (12 September 2012)
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Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development
Andrew D Cook, Jarrad Pobjoy, Stefan Steidl, Manuela Dürr, Emma L Braine, Amanda L Turner, Derek C Lacey, John A Hamilton Arthritis Research & Therapy 2012, 14:R199 (20 September 2012)
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Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment
Maria C Lebre, Christina L Jonckheere, Maarten C Kraan, Arno WR van Kuijk, Jan D Bos, Menno de Rie, Danielle M Gerlag, Paul P Tak Arthritis Research & Therapy 2012, 14:R200 (24 September 2012)
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Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides
Monika Hansson, Linda Mathsson, Thomas Schlederer, Lena Israelsson, Per Matsson, Leonor Nogueira, Per-Johan Jakobsson, Karin Lundberg, Vivianne Malmström, Guy Serre, Rikard Holmdahl, Mats Nystrand, Lars Klareskog, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R201 (1 October 2012)
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Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties
Valentina Calamia, Lucía Lourido, Patricia Fernández-Puente, Jesús Mateos, Beatriz Rocha, Eulalia Montell, Josep Vergés, Cristina Ruiz-Romero, Francisco J Blanco Arthritis Research & Therapy 2012, 14:R202 (2 October 2012)
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Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis
Derek L Mattey, Nicola B Nixon, Peter T Dawes Arthritis Research & Therapy 2012, 14:R204 (2 October 2012)
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Chondrocalcinosis is common in the absence of knee involvement
Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty Arthritis Research & Therapy 2012, 14:R205 (4 October 2012)
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Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee
Walter P Maksymowych, Anthony S Russell, Peter Chiu, Alex Yan, Niall Jones, Tracey Clare, Robert GW Lambert Arthritis Research & Therapy 2012, 14:R206 (4 October 2012)
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Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor-binding protein 3 (IGFBP-3) in human chondrocytes
Giorgio Gasparini, Marco De Gori, Francesco Paonessa, Eusebio Chiefari, Antonio Brunetti, Olimpio Galasso Arthritis Research & Therapy 2012, 14:R207 (4 October 2012)
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Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis
Marina G Kazantseva, John Highton, Lisa K Stamp, Paul A Hessian Arthritis Research & Therapy 2012, 14:R208 (4 October 2012)
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Impaired skeletal muscle microcirculation in systemic sclerosis
Sasan Partovi, Anja-Carina Schulte, Markus Aschwanden, Daniel Staub, Daniela Benz, Stephan Imfeld, Björn Jacobi, Pavel Broz, Kurt A Jäger, Martin Takes, Rolf W Huegli, Deniz Bilecen, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R209 (4 October 2012)
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TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation
Hye Kim, Doo Chung Arthritis Research & Therapy 2012, 14:R210 (4 October 2012)
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Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-α blockers treatment: a prospective study
Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Roberta Lupoli, Anna Russolillo, Giovanni Tarantino, Raffaele Scarpa Arthritis Research & Therapy 2012, 14:R211 (4 October 2012)
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Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging
Jesper Knoop, Joost Dekker, Jan-Paul Klein, Marike van der Leeden, Martin van der Esch, Dick Reiding, Ramon E Voorneman, Martijn Gerritsen, Leo D Roorda, Martijn PM Steultjens, Willem F Lems Arthritis Research & Therapy 2012, 14:R212 (5 October 2012)
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Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study
Gene-Siew Ngian, Wendy Stevens, David Prior, Eli Gabbay, Janet Roddy, Ai Tran, Robert Minson, Catherine Hill, Ken Chow, Joanne Sahhar, Susanna Proudman, Mandana Nikpour Arthritis Research & Therapy 2012, 14:R213 (5 October 2012)
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Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre, Edward Flynn, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, BRAGGGSS, Anne Barton Arthritis Research & Therapy 2012, 14:R214 (7 October 2012)
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Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study
Yan Li, Shengli Zhang, Jian Zhu, Xuna Du, Feng Huang Arthritis Research & Therapy 2012, 14:R215 (11 October 2012)
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Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy?
Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa, Rosa MR Pereira Arthritis Research & Therapy 2012, 14:R216 (12 October 2012)
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Editor’s summary
Persistent low serum levels of the Wnt inhibitor sclerostin are associated with continuous inflammation in patients with ankylosing spondylitis being treated with anti-TNF therapy.
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A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia
Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki, Kusuki Nishioka Arthritis Research & Therapy 2012, 14:R217 (12 October 2012)
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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity
Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran, Bidyut K Das Arthritis Research & Therapy 2012, 14:R218 (15 October 2012)
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Does digital X-ray radiogrammetry have a role in identifying patients at increased risk for joint destruction in early rheumatoid arthritis?
Kristina Forslind, Johan Kälvesten, Ingiäld Hafström, Björn Svensson, for the BARFOT Study Group Arthritis Research & Therapy 2012, 14:R219 (15 October 2012)
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Editor’s summary
Change in bone mineral density measured by digital X-ray radiogrammetry (DXR) in the first year of rheumatoid arthritis is associated with progression of radiographic joint damage over a number of years.
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Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis
Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch, Martin Laudien Arthritis Research & Therapy 2012, 14:R203 (17 October 2012)
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Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012)
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Editor’s summary
Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.
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Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study
Menke Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer, Arie van Winkelhoff Arthritis Research & Therapy 2012, 14:R222 (17 October 2012)
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Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis
Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2012, 14:R223 (18 October 2012)
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Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates
Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase, Koichi Wauke Arthritis Research & Therapy 2012, 14:R224 (18 October 2012)
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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2
Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz Arthritis Research & Therapy 2012, 14:R225 (18 October 2012)
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Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza, Mark S Cooper Arthritis Research & Therapy 2012, 14:R226 (18 October 2012)
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Th17 expansion in granulomatosis with polyangiitis (Wegener's): the role of disease activity, immune regulation and therapy
Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Marc Hilhorst, Pieter van Paassen, Oliver Witzke, Jan Cohen Tervaert Arthritis Research & Therapy 2012, 14:R227 (18 October 2012)
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Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis
Fang Wang, Lingxiao Xu, Xiaoke Feng, Dunming Guo, Wenfeng Tan, Miaojia Zhang Arthritis Research & Therapy 2012, 14:R228 (19 October 2012)
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The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy
Feng Fang, Lei Liu, Yang Yang, Zenshiro Tamaki, Jun Wei, Roberta G Marangoni, Swati Bhattacharyya, Ross S Summer, Boping Ye, John Varga Arthritis Research & Therapy 2012, 14:R229 (23 October 2012)
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Editor’s summary
Activation of the adiponectin pathway has potent antifibrotic effects in normal and scleroderma fibroblasts, and is a potential therapeutic target to control fibrosis in scleroderma and other chronic fibrosing conditions.
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Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement
Gerd Horneff, Sigrid Fitter, Ivan Foeldvari, Kirsten Minden, Jasmin Kuemmerle-Deschner, Nicolay Tzaribacev, Angelika Thon, Michael Borte, Gerd Ganser, Rolf Trauzeddel, Hans-Iko Huppertz Arthritis Research & Therapy 2012, 14:R230 (24 October 2012)
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Editor’s summary
A double-blind randomized trial found adalimumab treatment was significantly superior to placebo in the treatment of juvenile onset ankylosing spondylitis (AS), being well tolerated and highly effective.
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Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing
Claudia M Campbell, Lea McCauley, Sara C Bounds, Vani A Mathur, Lora Conn, Mpepera Simango, Robert R Edwards, Kevin R Fontaine Arthritis Research & Therapy 2012, 14:R231 (25 October 2012)
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Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
Athanassios Fragoulis, Jendrik Laufs, Susanna Müller, Ulf Soppa, Stephanie Siegl, Lucy Reiss, Mersedeh Tohidnezhad, Christian Rosen, Klaus Tenbrock, Deike Varoga, Sebastian Lippross, Thomas Pufe, Christoph Wruck Arthritis Research & Therapy 2012, 14:R220 (27 October 2012)
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Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate
Sang-Won Lee, Hee-Jin Park, Beom Kim, Kwang-Hyub Han, Soo-Kon Lee, Seung Kim, Yong-Beom Park Arthritis Research & Therapy 2012, 14:R232 (29 October 2012)
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Editor’s summary
Cumulative dose of leflunomide correlated closely with the presence of silent liver fibrosis in rheumatoid arthritis patients treated with methotrexate.
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Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy
Nils Venhoff, Dirk Lebrecht, Dietmar Pfeifer, Ana C Venhoff, Emmanuel Bissé, Janbernd Kirschner, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R233 (29 October 2012)
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Correspondence |
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Response to 'Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice'
Gn Kim, Think-You Kim Arthritis Research & Therapy 2012, 14:404 (10 September 2012)
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Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4'
Francesca Oliviero, Anna Scanu, Jean-Michel Dayer, Ugo Fiocco, Paolo Sfriso, Leonardo Punzi Arthritis Research & Therapy 2012, 14:405 (12 September 2012)
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Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply
Dong Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson Arthritis Research & Therapy 2012, 14:406 (12 September 2012)
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