Angiotensin II increases collagen synthesis and deposition in mouse skin. (A) Gomori Trichrome staining shows a histologic evaluation of Ang II-induced lesions in C57BL/6 mice. (B) Real-time PCR analysis of collagen-encoding genes: Col1a1, Col1a2, Col3a1, Col5a1, along with CTGF (*P ≤ 0.05) in PBS-and Ang II-treated mice. (C) Total hydroxyproline content in PBS- and Ang II-treated mice. Values are the mean of six mice in each group; *P ≤ 0.05.
Stawski et al. Arthritis Research & Therapy 2012 14:R194 doi:10.1186/ar4028