Table 1

Binding analysis of 2H- and ILZ-based stradomers to individual FcRs

FcγRI

FcγRIIb

FcγRIII

FcγRIV

SIGN-R1


IgG2a Fc

17.4 (4.07)

289 (1.48)

248 (2.9)

27.8 (25.4)

n.s.a

2A-ILZN

6.71 (52.9)

3.8 (51.3)

2.3 (85.4)

.46 (88.3)

134 (0.43)

2A-ILZC

63.4 (7.62)

455 (11)

151 (16.1)

63.6 (20)

43.9 (0.77)

2A-2HN

16.3 (7.62)

3.4 (12.1)

4.4 (24.9)

7.6 (11.3)

109 (0.11)

2A-2HC

9.12 (9.97)

3.3 (29.2)

4.2 (40.6)

3.03 (18.9)

n.s.a


KD (left, in nM), and χ2 (right, in parenthesis). aInsufficient binding to calculate KD.

Jain et al. Arthritis Research & Therapy 2012 14:R192   doi:10.1186/ar4024

Open Data