Table 1 |
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|
Binding analysis of 2H- and ILZ-based stradomers to individual FcRs |
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|
FcγRI |
FcγRIIb |
FcγRIII |
FcγRIV |
SIGN-R1 |
|
|
|
|||||
|
IgG2a Fc |
17.4 (4.07) |
289 (1.48) |
248 (2.9) |
27.8 (25.4) |
n.s.a |
|
2A-ILZN |
6.71 (52.9) |
3.8 (51.3) |
2.3 (85.4) |
.46 (88.3) |
134 (0.43) |
|
2A-ILZC |
63.4 (7.62) |
455 (11) |
151 (16.1) |
63.6 (20) |
43.9 (0.77) |
|
2A-2HN |
16.3 (7.62) |
3.4 (12.1) |
4.4 (24.9) |
7.6 (11.3) |
109 (0.11) |
|
2A-2HC |
9.12 (9.97) |
3.3 (29.2) |
4.2 (40.6) |
3.03 (18.9) |
n.s.a |
|
|
|||||
|
KD (left, in nM), and χ2 (right, in parenthesis). aInsufficient binding to calculate KD. |
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|
Jain et al. Arthritis Research & Therapy 2012 14:R192 doi:10.1186/ar4024 |
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