Stradomers effectively treat CIA. Stradomers were tested in a treatment model of murine CIA. Treatment was initiated after mice had an average arthritis score of 3.3. Each paw was scored individually for arthritis (0 to 4), and the sum of all four paws was used as the score for the animal (maximum of 16). The positive treatment control for these experiments was oral prednisolone at 10 mg/kg daily. (A) Direct comparison of stradomers in the CIA model. (B) Comparison of 2A-2HC efficacy against IVIG. (C) Comparison of the 2A-2HC homodimeric and multimeric fractions. (*Significant compared with no treatment, with Bonferroni correction). The 2A-2HC dose-response experiments were performed by a separate contract organization that used a different arthritis-scoring system. Each paw was scored on a scale of 0 to 5. The average of all four paws (rather than the sum) was used as the score for the animal. (D) Dose-response curve of 2A-2HC. Treatment control for this experiment was oral dexamethasone at 0.2 mg/kg daily.
Jain et al. Arthritis Research & Therapy 2012 14:R192 doi:10.1186/ar4024