Table 3 |
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Clinical outcomes by age at menopause |
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Early menopause (< 46 years) (n = 25)a |
Normal/late menopause (≥ 46 years) (n = 102)a |
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|
|
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Mean age at diagnosis; years (SD) |
65.2 (6.94) |
62.8 (8.48) |
|
|
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|
Mean follow-up time; years (SD) |
10.5 (3.0) |
10.1 (3.6) |
|
|
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|
> 3 DMARDs used (%) |
5/25 (20.0) |
23/101 (22.8) |
|
|
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|
DMARDs in combination (%) |
8/25 (32.0) |
45/101 (44.6) |
|
|
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|
Biological treatment ever (%) |
3/25 (12.0) |
33/101 (32.7) |
|
|
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|
Documented radiographic erosions (ever) (%) |
14/23 (60.9) |
52/96 (54.2) |
|
|
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|
RF positive (%) |
11/25 (44.0) |
78/100 (78.0) |
|
|
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|
Mean HAQ at diagnosis (CI)b |
0.58 (0.22-0.93) (n = 12) |
0.96 (0.79-1.12) (n = 55) |
|
|
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|
Mean HAQ 1 year after diagnosis (CI)b |
0.45 (0.08-0.83) (n = 12) |
0.86 (0.70-1.02) (n = 65) |
|
|
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|
Mean HAQ 5 years after diagnosis (CI)b |
0.88 (0.60-1.15) (n = 19) |
0.90 (0.76-1.05) (n = 68) |
|
|
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|
Mean HAQ 10 years after diagnosis (CI)b |
0.67 (0.34-1.00) (n = 12) |
0.98 (0.82-1.14) (n = 49) |
|
|
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|
Cluster distribution (P = 0.005) |
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|
Severe RA (%) |
3 (15.8%) |
23 (34.8%) |
|
Mild/moderate seropos RA (%) |
5 (26.3%) |
30 (45.5%) |
|
Mild/moderate seroneg RA (%) |
11 (57.9%) |
13 (19.7%) |
|
|
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|
CI, confidence Interval; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SD, standard deviation. aIn case of missing data, numbers (n) indicated for each variable. bAdjusted for age at diagnosis. |
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|
Pikwer et al. Arthritis Research & Therapy 2012 14:R190 doi:10.1186/ar4021 |
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