Table 3

Clinical outcomes by age at menopause

Early menopause

(< 46 years) (n = 25)a

Normal/late menopause

(≥ 46 years) (n = 102)a


Mean age at diagnosis; years (SD)

65.2 (6.94)

62.8 (8.48)


Mean follow-up time; years (SD)

10.5 (3.0)

10.1 (3.6)


> 3 DMARDs used (%)

5/25 (20.0)

23/101 (22.8)


DMARDs in combination (%)

8/25 (32.0)

45/101 (44.6)


Biological treatment ever (%)

3/25 (12.0)

33/101 (32.7)


Documented radiographic erosions (ever) (%)

14/23 (60.9)

52/96 (54.2)


RF positive (%)

11/25 (44.0)

78/100 (78.0)


Mean HAQ at diagnosis (CI)b

0.58 (0.22-0.93) (n = 12)

0.96 (0.79-1.12) (n = 55)


Mean HAQ 1 year after diagnosis (CI)b

0.45 (0.08-0.83) (n = 12)

0.86 (0.70-1.02) (n = 65)


Mean HAQ 5 years after diagnosis (CI)b

0.88 (0.60-1.15) (n = 19)

0.90 (0.76-1.05) (n = 68)


Mean HAQ 10 years after diagnosis (CI)b

0.67 (0.34-1.00) (n = 12)

0.98 (0.82-1.14) (n = 49)


Cluster distribution (P = 0.005)

Severe RA (%)

3 (15.8%)

23 (34.8%)

Mild/moderate seropos RA (%)

5 (26.3%)

30 (45.5%)

Mild/moderate seroneg RA (%)

11 (57.9%)

13 (19.7%)


CI, confidence Interval; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SD, standard deviation. aIn case of missing data, numbers (n) indicated for each variable. bAdjusted for age at diagnosis.

Pikwer et al. Arthritis Research & Therapy 2012 14:R190   doi:10.1186/ar4021

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