Table 4

FCU values in percentage (mean ± SD) extracted and calculated from the literature in healthy and gouty subjects

Reference

Healthy subjects (n)

Gouty subjects (n)

Unclassified

Under

excretion

Normoexcretion

Overproduction

[19]

-

-

-

5.4 ± 1.0 (5)

6.8 ± 1.6 (8)

[20]

6.9 (36)

-

4.5 (78)

6.0 (46)

-

[21]

-

-

4.3 (26)

-

5.8 (23)

[22]

6.5 ± 2.5 (5)

-

-

-

-

[23]

9.9 ± 1.5 (9)

-

-

-

-

[24]

7.0 ± 1.6 (7)

-

-

5.8 ± 1.3 (10)

8.7 ± 2.7 (6)

[25]

6.9 ± 1.3 (10)

5.1 ± 1.9 (11)

-

-

-

[7]

7.9 ± 3.0 (41)

4.4 ± 1.4

(11 hyperuricemic)

-

-

-

-

[26]

11.1 [female]

8.2 [male]

(n = 3,224)

-

-

-

-

[27]

8.1 ± 3.2

(51 male)

12.8 ± 2.9

(14 female)

-

-

-

-

[28]

7.6 ± 1.9 (72)

4.6 ± 1.2 (100)

-

-

-

FCU, fractional clearance of urate. Definitions of excretor phenotype as described by respective authors (expressed as percentage per 1.73 m² body-surface area, where possible). Underexcretion, urinary urate < 826 mg/day/1.73 m² [20]; urate clearance < 6 ml/min/1.73 m² [21]. Normoexcretion, urinary urate < 720 mg/day/1.73 m² [19]; > 830 mg/day/1.73 m²) [20]; urate clearance, > 6 ml/min/1.73 m² [21]; urinary urate < 700 mg/day/1.73 m² [24]. Overproduction, urinary urate > 720 mg/day/1.73 m² [19]; > 700 mg/day/1.73 m² [24].

Kannangara et al. Arthritis Research & Therapy 2012 14:R189   doi:10.1186/ar4020