Table 3 |
||||
|
The effect of allopurinol, probenecid, and the combination on fractional clearance of urate in healthy subjects |
||||
|
Subject |
FCU (%) |
|||
|
|
||||
|
Baseline |
A |
P |
A + P |
|
|
|
||||
|
H01 |
4.5 |
5.7 |
8.3 |
14.9 |
|
H02 |
8.1 |
8.5 |
25.9 |
24.1 |
|
H03 |
12.1 |
7.9 |
34.0 |
33.4 |
|
H04 |
4.8 |
5.4 |
22.6 |
26.2 |
|
H05 |
8.2 |
7.4 |
22.9 |
31.7 |
|
H06 |
10.2 |
10.0 |
23.1 |
21.5 |
|
H07 |
5.3 |
3.9 |
19.6 |
23.8 |
|
H08 |
2.5 |
5.8 |
16.2 |
21.4 |
|
H09 |
11.5 |
10.3 |
27.4 |
22.1 |
|
H10 |
12.5 |
7.5 |
30.8 |
30.1 |
|
H11 |
7.5 |
6.4 |
17.5 |
22.9 |
|
|
||||
|
Mean |
7.9 |
7.2 |
22.6 |
24.7 |
|
|
||||
|
95% CI |
5.7 to 10.2 |
5.8 to 8.5 |
17.8 to 27.4 |
21.1 to 28.3 |
|
|
||||
|
Study 1C; n = 11. A, allopurinol; P, probenecid; A + P, the combination. Mean age (range) was 24 (21 to 36) years. |
||||
|
Kannangara et al. Arthritis Research & Therapy 2012 14:R189 doi:10.1186/ar4020 |
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