Table 3

The effect of allopurinol, probenecid, and the combination on fractional clearance of urate in healthy subjects

Subject

FCU (%)


Baseline

A

P

A + P


H01

4.5

5.7

8.3

14.9

H02

8.1

8.5

25.9

24.1

H03

12.1

7.9

34.0

33.4

H04

4.8

5.4

22.6

26.2

H05

8.2

7.4

22.9

31.7

H06

10.2

10.0

23.1

21.5

H07

5.3

3.9

19.6

23.8

H08

2.5

5.8

16.2

21.4

H09

11.5

10.3

27.4

22.1

H10

12.5

7.5

30.8

30.1

H11

7.5

6.4

17.5

22.9


Mean

7.9

7.2

22.6

24.7


95% CI

5.7 to 10.2

5.8 to 8.5

17.8 to 27.4

21.1 to 28.3


Study 1C; n = 11. A, allopurinol; P, probenecid; A + P, the combination. Mean age (range) was 24 (21 to 36) years.

Kannangara et al. Arthritis Research & Therapy 2012 14:R189   doi:10.1186/ar4020

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