Table 1

Fractional clearance of urate (%) in healthy subjects derived from timed urine collections within a 24-hour period

Subject

Spot am

12-hour overnight

2-hour

4-hour

6-hour

24-hour


H01

8.0

5.7

9.9

9.7

7.0

7.1

H02

7.1

3.4

9.0

12.6

7.9

6.6

H03

6.3

3.0

10.6

6.8

6.7

4.8

H04

6.3

5.3

8.5

6.0

8.1

6.4

H05

5.2

3.8

5.2

7.1

6.7

5.2

H06

6.3

5.3

8.5

7.9

7.0

6.4

H07

8.4

6.7

14.3

8.1

7.5

7.8

H08

6.4

7.0

9.0

6.9

7.4

7.3

H09

4.3

2.2

3.0

5.1

6.1

3.8

H10

10.7

11.9

15.8

16.4

12.0

11.1

H11

11.3

2.1

7.1

6.3

9.7

5.8

H12

8.8

7.3

8.5

9.5

7.7

7.9


Mean

7.4

5.3a

9.1b

8.5

7.8

6.9b


95% CI

6.1 to 8.8

3.6 to 7.1

6.9 to 11.3

6.5 to 10.6

7.0 to 8.8

5.4 to 8.3


Study 1A, n = 12. Urine collection began at 2000 hours with the 12-hour overnight collection. a Statistically significant difference when compared with other collection periods (P < 0.05). bStatistically significant difference when compared with each other (P < 0.05).

Kannangara et al. Arthritis Research & Therapy 2012 14:R189   doi:10.1186/ar4020

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