Table 1 |
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|
Fractional clearance of urate (%) in healthy subjects derived from timed urine collections within a 24-hour period |
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|
Subject |
Spot am |
12-hour overnight |
2-hour |
4-hour |
6-hour |
24-hour |
|
|
||||||
|
H01 |
8.0 |
5.7 |
9.9 |
9.7 |
7.0 |
7.1 |
|
H02 |
7.1 |
3.4 |
9.0 |
12.6 |
7.9 |
6.6 |
|
H03 |
6.3 |
3.0 |
10.6 |
6.8 |
6.7 |
4.8 |
|
H04 |
6.3 |
5.3 |
8.5 |
6.0 |
8.1 |
6.4 |
|
H05 |
5.2 |
3.8 |
5.2 |
7.1 |
6.7 |
5.2 |
|
H06 |
6.3 |
5.3 |
8.5 |
7.9 |
7.0 |
6.4 |
|
H07 |
8.4 |
6.7 |
14.3 |
8.1 |
7.5 |
7.8 |
|
H08 |
6.4 |
7.0 |
9.0 |
6.9 |
7.4 |
7.3 |
|
H09 |
4.3 |
2.2 |
3.0 |
5.1 |
6.1 |
3.8 |
|
H10 |
10.7 |
11.9 |
15.8 |
16.4 |
12.0 |
11.1 |
|
H11 |
11.3 |
2.1 |
7.1 |
6.3 |
9.7 |
5.8 |
|
H12 |
8.8 |
7.3 |
8.5 |
9.5 |
7.7 |
7.9 |
|
|
||||||
|
Mean |
7.4 |
5.3a |
9.1b |
8.5 |
7.8 |
6.9b |
|
|
||||||
|
95% CI |
6.1 to 8.8 |
3.6 to 7.1 |
6.9 to 11.3 |
6.5 to 10.6 |
7.0 to 8.8 |
5.4 to 8.3 |
|
|
||||||
|
Study 1A, n = 12. Urine collection began at 2000 hours with the 12-hour overnight collection. a Statistically significant difference when compared with other collection periods (P < 0.05). bStatistically significant difference when compared with each other (P < 0.05). |
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|
Kannangara et al. Arthritis Research & Therapy 2012 14:R189 doi:10.1186/ar4020 |
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