The effects of atorvastatin on cell viability and apoptosis. (A) Effects of atorvastatin on the viability of FLSs from an RA patient (patients 1, 2, and 3). Cells were cultured for 24 hours in the presence of TNF-α (20 ng/ml) and atorvastatin at different concentrations (10 to 100 μM). Cell viabilities were determined by using MTT assays. (B) Effects of atorvastatin on the apoptosis of FLSs as determined by propidium iodide staining.
Kim et al. Arthritis Research & Therapy 2012 14:R187 doi:10.1186/ar4018